Chromatography and Analytical Techniques

High-Throughput Screening

High-throughput screening (HTS) is pivotal in drug discovery, biomarker identification, and clinical research, where large volumes of samples must be processed rapidly and accurately. Chromatographic techniques—particularly UHPLC and multiplexed LC-MS systems have evolved to meet these demands by enabling ultra-fast separation, minimal sample consumption, and automated operation. With parallel processing, miniaturized platforms, and robotic integration, HTS allows simultaneous analysis of hundreds to thousands of samples per day. The pharmaceutical and biotechnology industries use HTS for lead compound screening, metabolic profiling, and pharmacokinetic evaluations. Moreover, advances in software for data processing and interpretation, including AI and machine learning tools, are accelerating discovery cycles and enhancing decision-making. Integration with other high-throughput modalities such as mass spectrometry imaging and microarrays offers comprehensive profiling capabilities. This session covers the recent advancements, automation strategies, and analytical precision of chromatography in HTS environments, emphasizing how scalable and efficient techniques are reshaping the speed and scope of modern research and development.