Steven J Soldin
Steven J Soldin National Institutes of Health USA, USA
Title: The role of mass spectrometry in improving the diagnosis and treatment of patients with adrenal diseases
Biography
Biography: Steven J Soldin
Abstract
A state-of-the-art isotope dilution LC-MS/MS method was developed for the simultaneous measurement of nine steroids. Diurnal reference intervals were determined and published. The method was then employed to assess patients with different forms of adrenal disease. We found that after ACTH stimulation the two best markers of adrenal reserve were 11-DOC and corticosterone. Studies are currently underway further validating this statement. Cortisol should no longer be regarded as the most reliable test to perform after ACTH stimulation of the adrenals. Our studies with the new markers reveal a possible prior misclassification rate of 20%.